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The Duncan Lab uses mammalian model systems mouse, bovine, and human to investigate the overarching hypothesis that deterioration of oocyte-intrinsic cellular pathways together with alterations in the ovarian environment underlie the age-associated decline in female gamete quantity and quality. Reproductive aging has a large societal impact as women globally are delaying childbearing and many women of advanced reproductive age rely on Assisted Reproductive Technologies ART to conceive. About Our Lab The female reproductive system is the first to age in the human body and will affect every single woman. Duncan Lab Feinberg. Reproductive aging is characterized by a noticeable decline in egg quantity and quality beginning in women when they reach their mid-thirties and continuing until menopause. Duncan, PhD. The female reproductive system is the first to age in the human body and will affect every single woman.
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